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Several large observational studies have suggested that vitamin E supplementation lowers the risk of coronary heart disease. However, the results of large randomized controlled trials failed to show a clear benefit of a-tocopherol supplementation on cardiovascular outcomes.

Does Lowering Gamma-tocopherol Explain the Failure of Vitamin E Supplementation Trials?

Several large observational studies have suggested that vitamin E supplementation lowers the risk of coronary heart disease. However, the results of large randomized controlled trials failed to show a clear benefit of a-tocopherol supplementation on cardiovascular outcomes.