The Mayo Clinic Cohort Study of Oophorectomy and Aging included 1274 premenopausal women with unilateral oophorectomy (followed for a median of 29.5 years) and 1091 premenopausal women with bilateral oophorectomy (followed for a median of 25 years) who had surgery from 1950 through 1987, compared with 2383 matched women from the same population of women who had not undergone oophorectomy.
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